Molecular characterization of the gene encoding high-level mupirocin resistance in Staphylococcus aureus J2870.
نویسندگان
چکیده
The nucleotide sequence of the ileS gene conferring high-level resistance to mupirocin in Staphylococcus aureus J2870 has been determined. The gene sequence is substantially different from that of the native ileS gene of S. aureus, indicating that high-level resistance to mupirocin results from the acquisition of a novel ileS gene.
منابع مشابه
شناسایی مقاومت به موپیروسین در سویه‌های استافیلوکوکوس اورئوس جدا شده از بیماران 4 بیمارستان دانشگاهی تهران با روش PCR
Introduction: Mupirocin, an inhibitor of bacterial isoleucyl-tRNA synthetase, has used to treat staphylococcal skin infections as well as to eliminate nasal carriage of Staphylococcus aureus. Mupirocin resistant Staphylococcus aureus strains are seen worldwide but there is no report from Iran. In the present study, by using phenotyping methods (disk diffusion and E-test) in combination with P...
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متن کاملآنالیز مولکولی و تایپینگ سویه های استافیلوکوکوس اورئوس مقاوم به متی سیلین جدا شده از بیماران بستری در بیمارستان
Background: The prevalence of Staphylococcus aureus, as one of the most common nosocomial pathogens, is increasing annually and is becoming a major public health concern. One of the serious threats associated with clinical isolates of MRSA is lack of data regarding the molecular characterization of these isolates. The aim of the present study was to identify resistance encoding genes and mol...
متن کاملMupirocin Resistance in Methicillin Resistant Staphylococcus Aureus
Mupirocin is the topical antimicrobial agent which is used for the treatment of methicillin resistant Staphylococcus aureus (MRSA). However the prevalence of mupirocin resistance in MRSA has increased with the extensive and widespread use of this agent in hospital settings. The present study was attempted to evaluate the low level and high level resistance to mupirocin in MRSA isolates by diffe...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 38 5 شماره
صفحات -
تاریخ انتشار 1994